MGN-3 Research Data

MGN-3 Research Abstract 

SYNERGISTIC EFFECT OF MODIFIED ARABINOXYLANE
(MGN-3) AND LOW DOSE OF RECOMBINANT IL-2 ON
HUMAN NK CELL ACTIVY AND TNF-a PRODUCTION
 
 

AMERICAN ACADEMY OF ANTI-AGING  MEDICINE Abstract #6 SYNERGISTIC EFFECT OF MODIFIED ARABINOXYLANE (MGN-3) AND LOW DOSE OF RECOMBINANT IL-2 ON HUMAN NK CELL ACTIVITY AND TNF-a PRODUCTION Mamdooh Ghoneum, Ph.D. and Anahid Jewett,, Ph.D.  Drew University of Medicine and Science and  UCLA School of Medicine and Dentistry Los Angeles, California  We have recently showed the potent biological response modification of a new product called MGN-3, an arabinoxylane from rice bran that has been modified by extract from Hyphomycetes mycelia.  MGN-3 possess anti-HIV activity, NK immuno- modulation and anti-cancer activity. Success with recombinant IL-2 (rlL-2) immunotherapy of human cancer appears to depend on the administration of high doses, which are frequently associated with excessive toxicity. Therefore, certain modifications are greatly needed on the use of rIL-2 at low doses without significant loss of anti-tumor efficacy.  Experiments were designed to examine NK activity post culture human peripheral blood lymphocytes (PBL) with of MGN-3 alone (Img/ml), rIL-2 alone (500u/ml) and MGN-3 (Img/ml) plus rIL-2 (500u/ml). Results showed that MGN-3 and rIL-2 increase NK activity by 138.6% and 179.5% respectively. Interestingly a synergistic effect on NK activity was noticed post culture of PBL with MGN-3 and rIL-2 (332.7% of control).  The mechanism underlying this phenomenon is not fully understood but could be attributed to action of MGN-3 on TNF-a production. Results showed that TNF- a levels from control untreated PBL of 20 subjects was 195 pg/rnl ±102. Treatment with rIL-2 showed no change in TNF-a level (216pg/ml ±100), while MGN-3 significantly increased TNF-a production (5773pg/ml ±2653).  On the other hand, a synergistic effect of MGN-3 plus rIL-2 resulted in a further increase of TNF-a production (8127pg/ml ±2578  We conclude that,  1) MGN-3 is a potent TNF-Aa producer, and  2) the imrnunomodulatory function by low concentration of rIL-2 on anti-tumor activity by NK cells could be greatly augmented by the concomitant use of MGN-3.     1341 W. Fullerton, Suite 111 Chicago, lllinois 60614 Phone:773-528-4333 Fax:773-528-5390 http://www.worldhealth.net A4M@worldhealth.net

PRESIDENT Dr.Ronald Klatz  CHAIRMAN OF THE BOARD  VICE PRESIDENT -  NORTH AMERICA  Dr. Robert M. Goldman VICE PRESIDENT -  EUROPE  Rafael Santonia   Gomez Pharm.D. Olympic Committee- Spain VICE PRESIDENT  - ASIA Dr. S. Arumainathan Health Ministry - Malaysia AMERICAN BOARD  OF ANTI-AGING MEDICINE CHAIRMAN  Dr. Vincent Giampapa EDUCATION  SPECIAL ADVISOR  Vernon Howard Ph.D.  Harvard University Graduate School of Education BOARD OF SCIENTIFIC  ADVISORS NORTH AMERICA  Dr. Ronald Lawrence UCLA School of Medicine Dr. Chong Park Longevity Institute  International Dr. Stephen Sinatra  Manchester Medical Hospital, CT Luke Bucci   Ph.D. University of Utah  Dr. Dharma Khalsa  University of Arizona  Donald Owen Ph.D. Louisiana State University Ben Weider Ph.D.  President, IFBB ASIA  Dr. S. Kim - Korea  Dr. R. Suahato  - Indonesia  Dr. S. Chua  - China Dr. C. Chaiwat Charaporn  -Thailand  Dr. Robert Tien  - Singapore EUROPE  Dr. Thierry Hertoghe  - Belgium  Dr. Juan Marcos Becerro - Spain INFINITY AWARD  RECIPIENTS  Dr. Roy Wa Ifo  rd Caloric restriction  mechanisms of aging Nathan Praikin Ph.D.  Cholesterol and dietar.v riskfactors for coronary  artery disease Linus Pauling Ph.D.  Nobel Laureate  Vitamin C and  megadose vitamin role in health Dr. Raymond Damadian  MRI Scanner  Dr. Daniel Rudman hGH role in aging  Dr. Karl Folkers Dr. Denham Harman  Free radical theory  of aging  Richard Cufler Ph.D.  Antioxidants role in aging Dr. Peter Safer  Cardiopulmonar.v  Resuscitation

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