Biochemical AND BIOPHYSICAL
RESEARCH COMMUNICATIONS 243, 25-29 (1998)
ARTICLE No. RC978047
Anti-HIV Activity in
Vitro of MGN-3, an Activated Arabinoxylane from Rice Bran
Department of Otolaryngology,
Drew University of Medicine and Science, 1621 E. 120th Street, Los Angeles,
Received December 19,
an arabinoxylane from rice bran that has been enzymatically modified with
extract from Hyphomycetes mycelia, was tested for anti-HIV activity
activity against HIV-1 (SF strain) was examined in primary cultures of
peripheral blood mononuclear cells.
inhibited HIV-1 replication by:
inhibition of HIV-1 p24 antigen production in a dose dependent manner-MGN-3
at concentrations of 12.5, 25, 50, and 100 µg/ml showed 18.3, 42.8,
59, and 75% reduction in p24 antigen, respectively; and
inhibition of syncytia formation maximized (75%) at concentrations of 100ug/ml.
studies showed that ingestion of MGN-3 at concentration of 15 mg/kg resulted
in a significant increase in T and B cell mitogen response at 2 months
after treatment: 146% for PHA, 140% for Con A, and 136.6% for PWM mitogen.
conclude that MGN-3 possesses potent anti-HIV activity and in the absence
of any notable side effects, MGN-3 shows promise as an agent for treating
patients with AIDS. 1998 Academic Press.
immunodeficiency virus (HIV) is the causative agent of the acquired immunodeficiency
syndrome (AIDS). HIV is one of the principal threats to human life worldwide.
to several sources (Center for Disease Control, American Red Cross, and
other public health agencies) there are approximately 1.5 million HIV infected
people in the United States and as many as 50 million worldwide. It has
been estimated that by the year 2000, 110 million will be infected with
HIV (2% of the world population). Drugs such as AZT and other nucleoside
analogues pose as major problems in slowing the progression of the disease.
the last AIDS International Conference held in Vancouver, Canada, there
was very little promise of a vaccine. The lack of vaccination or effective
treatment send alarming signals. Therefore, there is great interest and
need to identify anti-HIV agents that are not only active against the virus,
but also can potentiate the host immune system without having deleterious
we demonstrated that MGN-3, a modified arabinoxylane from rice bran, is
a potent biological response modifier (BRM) that is able to enhance natural
killer (NK) cell activity in cancer patients (1,2). In this study we showed
that MGN-3 inhibited HIV replication in patients' peripheral blood mononuclear
cells (MNC) as well as syncytia formation.
also increases T and B cell mitogen response upon ingestion. These studies
demonstrated MGN-3 has strong anti-HIV activity and may be of value in
combination therapy in the treatment of HIV-1 infected patients.