MGN-3 Research Data

MGN-3 Research Abstract 

Anti-HIV Activity in Vitro of MGN-3, an Activated Arabinoxylane from Rice Bran

Biochemical AND BIOPHYSICAL RESEARCH COMMUNICATIONS 243, 25-29 (1998)

ARTICLE No. RC978047 

Anti-HIV Activity in Vitro of MGN-3, an Activated Arabinoxylane from Rice Bran 

Mamdooh Ghoneum 

Department of Otolaryngology, Drew University of Medicine and Science, 1621 E. 120th Street, Los Angeles, California 90059

Received December 19, 1997 

MGN-3, an arabinoxylane from rice bran that has been enzymatically modified with extract from Hyphomycetes mycelia, was tested for anti-HIV activity invitro. 

MGN-3 activity against HIV-1 (SF strain) was examined in primary cultures of peripheral blood mononuclear cells. 

MGN-3 inhibited HIV-1 replication by: 

(1) inhibition of HIV-1 p24 antigen production in a dose dependent manner-MGN-3 at concentrations of 12.5, 25, 50, and 100 µg/ml showed 18.3, 42.8, 59, and 75% reduction in p24 antigen, respectively; and 

(2) inhibition of syncytia formation maximized (75%) at concentrations of 100ug/ml. 

Further studies showed that ingestion of MGN-3 at concentration of 15 mg/kg resulted in a significant increase in T and B cell mitogen response at 2 months after treatment: 146% for PHA, 140% for Con A, and 136.6% for PWM mitogen. 

We conclude that MGN-3 possesses potent anti-HIV activity and in the absence of any notable side effects, MGN-3 shows promise as an agent for treating patients with AIDS. 1998 Academic Press. 

Human immunodeficiency virus (HIV) is the causative agent of the acquired immunodeficiency syndrome (AIDS). HIV is one of the principal threats to human life worldwide. 

According to several sources (Center for Disease Control, American Red Cross, and other public health agencies) there are approximately 1.5 million HIV infected people in the United States and as many as 50 million worldwide. It has been estimated that by the year 2000, 110 million will be infected with HIV (2% of the world population). Drugs such as AZT and other nucleoside analogues pose as major problems in slowing the progression of the disease. 

At the last AIDS International Conference held in Vancouver, Canada, there was very little promise of a vaccine. The lack of vaccination or effective treatment send alarming signals. Therefore, there is great interest and need to identify anti-HIV agents that are not only active against the virus, but also can potentiate the host immune system without having deleterious side effects. 

Recently we demonstrated that MGN-3, a modified arabinoxylane from rice bran, is a potent biological response modifier (BRM) that is able to enhance natural killer (NK) cell activity in cancer patients (1,2). In this study we showed that MGN-3 inhibited HIV replication in patients' peripheral blood mononuclear cells (MNC) as well as syncytia formation. 

MGN-3 also increases T and B cell mitogen response upon ingestion. These studies demonstrated MGN-3 has strong anti-HIV activity and may be of value in combination therapy in the treatment of HIV-1 infected patients.

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