MGN-3 Research Data

MGN-3
  Research Abstract  Anti-HIV activity by MGN-3 In Vitro

Dr. Mamdooh Ghoneum

Drew University of medicine and science. Los Angeles, California 

Objective: To examine the effect of MGN-3 on HIV induced syncytia formation (SF) In Vitro. MGN-3 is an arabinoxylane from rice bran, that is enzymatically treated with an extract from Hyphomycetes mycelia. 

Method: Peripheral Blood Lymphocytes (PBL) from AIDS patients were cultured with PHA in the presence or absence of different concentrations of MGN-3 (12.5 - 100,v g / ml) for 7 days. The number of syncytia were evaluated, and the size of each was also recorded. The effect of MGN-3 on PHA induced PBL proliferation was studied by MTT
assay. 

Results: Treatment with MGN-3 resulted in:Significant inhibition in the SF,The effect was dose dependent, percentage of inhibition in SF was 38.5, 50, 62.5, and 75% at concentrations of 12.5, 25, 50, and 100 p g / ml respectively; Complete absence of SF having large and median size post treatment, and MGN-3 caused 25 - 30% inhibition of PBL proliferation.
 

Conclusion: We conclude that MGN-3 is a natural product that possesses a potent effect against syncytia formation by HIV. This property of MGN-3 may be of potential value in therapy of HIV infection.

Supported by Daiwa Pharmaceutical Co., Ltd.

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