Drew University of medicine and science. Los Angeles, California
examine the effect of MGN-3 on HIV induced syncytia formation (SF) In Vitro.
is an arabinoxylane from rice bran, that is enzymatically treated with
an extract from Hyphomycetes mycelia.
Blood Lymphocytes (PBL) from AIDS patients were cultured with PHA in the
presence or absence of different concentrations of MGN-3 (12.5 - 100,v
g / ml) for 7 days. The number of syncytia were evaluated, and the size
of each was also recorded. The effect of MGN-3 on PHA induced PBL proliferation
was studied by MTT
with MGN-3 resulted in:Significant inhibition in the SF,The effect was
dose dependent, percentage of inhibition in SF was 38.5, 50, 62.5, and
75% at concentrations of 12.5, 25, 50, and 100 p g / ml respectively; Complete
absence of SF having large and median size post treatment, and MGN-3 caused
25 - 30% inhibition of PBL proliferation.
conclude that MGN-3 is a natural product that possesses a potent effect
against syncytia formation by HIV. This property of MGN-3 may be of potential
value in therapy of HIV infection.
by Daiwa Pharmaceutical Co., Ltd.