MGN-3 Research Data

MGN-3
  Research Abstract 
EFFECT OF MGN-3 ON HUMAN NATURAL 
KILLER CELL ACTIVITY AND INTERFERON- y SYNTHESIS IN VITRO.

EFFECT OF MGN-3 ON HUMAN NATURAL KILLER CELL ACTIVITY AND INTERFERON- y SYNTHESIS IN VITRO.

M. Ghoneum. G.Namatalia and C. Kim. Drew University of Medicine and Science, Los Angeles, CA 90059, and University of California, Irvine, CA. 92717

FASEB JOURNAL

June 2-6, 1996, New Orleans, LA.

Abstract

MGN-3 is an extract of arabinoxylane from rice bran that has been enzymatically treated with an extract from Hyphomycetes mycelia. In this study we investigated the effect. MGN-3 on natural killer (NK) cell activity and interferon-y (IFN-y) synthesis by peripheral blood mononuclear cells (MNC). 

MNC was prepared from peripheral blood of healthy individuals and incubated with various concentrations of MGN-3 for 16 hrs., and then NK cell activity was measured by 4 hr. Cr-release assay using K56 Tumor cells as target NK activity was significantly enhanced (2-5 fold) by treatment with MGN-3 at 0-100 u g/ml. 

In an attempt to investigate the mechanism by which MGN-3 enhances NK activity, we examined the effect of MGN-3 on IFN-y production by MNC. Culture supernatants of the cells incubated with MGN-3 were collected and analyzed for INF-y synthesis by ELISA. INF-y production was increased >2 fold. 

We concluded that MGN-3 is a potent biological response modifier (BRM) and may be useful in immunotherapy of cancer. MGN-3. was offered by Daiwa Pharmaceutical Co. Ltd. Tokyo-Japan.

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