Science. September 1983,
Vol. 221: 1185-1187
Shark Cartilage Contains Inhibitors
of Tumor Angiogenesis
Anne Lee and Robert Langer Massachusetts Institute
to V2 carcinoma implanted in the cornea of New Zealand white rabbits was
measured to test the vascularization inhibiting ability of shark cartilage
to solid tumors. The tumors induced vessels to grow towards them from the
edge of the cornea. Table I shows the growth of blood vessels in the cornea
of rabbits with and without shark cartilage treatment. Three different
tests were conducted and the same result was observed in every test.
cartilage contains a substance that strongly inhibits the growth of new
blood vessels toward solid tumors, thereby restricting tumor growth.
is an angiogenesis inhibiting substance.
to Shark Cartilage index